Prevalence of human T-cell lymphotropic virus I and II in Colombian blood donors, 2001-2014: Implications for transfusion safety
Abstract
Introduction: The human T-cell lymphotropic virus (HTLV) 1 and 2 cause various clinical disorders associated with degenerative diseases. Blood transfusion is a primary mechanism of transmission that is associated with the use of cellular components such as red blood cells. Objective: To describe the epidemiology of HTLV 1 and 2 in blood donors in Colombia from 2001-2014. Materials and methods: A retrospective analysis was performed using screening, reactivity and positivity for HTLV 1 and 2 data collected from 2001 to 2014 by Colombian blood banks and consolidated by the Instituto Nacional de Salud. Using this information, transfusion-associated infectivity was also estimated. Results: From 2001 to 2014, 60.2% of blood collected in Colombia was screened for HTLV 1 and 2 and had a cumulative reactivity of 0.30%. This was 20 times higher in Chocó (6.28%), where blood collection ended in 2004. Blood screening for HTLV reached 94.9% in 2014 with a positive concordance of 14.7%, and an estimated 406 unscreened, potentially infectious blood units were released. The majority of the unscreened blood units (215 units, 53%) came from Antioquia, a non-endemic department. Conclusion: These results suggest that HTLV 1 and 2 infections are distributed in different areas of the country that were not previously classified as endemic. These findings support the importance of the universal screening of blood units to minimize the risk of infection through transfusion for this event.
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References
Romaní F. Revisión sistemática de estudios epidemiológicos sobre la infección por el virus linfotrópico de células T humanas I/II en el Perú. Revista Peruana de Epidemiología. 2010;14:1-9.
Dow BC, Fiebig EW, Busch MP. Retroviruses. En: Barbara JA, Regan FA, Contreras M, editors. Transfusion Microbiology. First edition. Cambridge: Cambridge University Press; 2008. p. 63.
Villaverde JA, Romaní FR, Torres SM, Zunt JR. Trans-misión vertical de HTLV-1 en el Perú. Rev Peru Med Exp Salud Pública. 2011;28:101-8. http://dx.doi.org/10.1590/S1726-46342011000100016
Proietti FA, Carneiro-Proietti AB, Catalan-Soares BC, Murphy EL. Global epidemiology of HTLV-I infection and associated diseases. Oncogene. 2005;24:6058-68. http://dx.doi.org/10.1038/sj.onc.1208968
Hlela C, Shepperd S, Khumalo NP, Taylor GP. The prevalence of human T-cell lymphotropic virus type 1 in the general population in unknown. AIDS Rev. 2009;11:205-14.
Gotuzzo E. Risk of transfusion-transmitted human T-cell lymphotropic virus-type I in Latin America. Int J Infect Dis. 2000;4:59-61. http://dx.doi.org/10.1016/S1201-9712(00) 90094-8
Gotuzzo E, Verdonck K, González E, Cabada M. Virus linfotrópico humano de células T tipo 1 (HTLV-1): una infección endémica en el Perú. Rev Peru Med Exp Salud Pública. 2004;21:253-60.
Zaninovic V, Arango C, Biojó R, Mora C, Rodgers-Johnson P, Concha M, et al. Tropical spastic paraparesis in Colombia. Ann Neurol. 1988;23(Supl.1):127-32.
Zamora T, Zaninovic V, Kajiwara M, Komoda H, Hayami M, Tajima K. Antibody to HTLV-I in indigenous inhabitants of the Andes and Amazon regions in Colombia. Jpn J Cancer Res. 1990;81:715-9.
Zaninovic V, Moreno D. A propósito de cinco casos de paraparesia espástica tropical en Puerto Tejada (Cauca). Colombia Médica. 1997;28:67-70.
Trujillo J, Concha M, Muñoz A, Bergonzoli G, Mora C, Borrero I. Seroprevalence and cofactors of HTLV-I infection in Tumaco, Colombia. AIDS Res Hum Retroviruses. 1992;8:651-7. http://dx.doi.org/10.1089/aid.1992.8.651
Rosero F, Aguirre C, Rosero M, Orjuela DL, Rosero A. Paraparesia espástica tropical en un paciente con HTLV-I. Neurología Argentina. 2011;3:229-33. http://dx.doi.org/10.1016/j.neuarg.2011.04.003
Carrascal E, Cortés A, Akiba S, Tamayo O, Quiñónez F. Epidemiología y patología de la leucemia/linfoma de las células T del adulto en Cali y el suroccidente colombiano. Colombia Médica. 2004;35:12-7.
Medina EA, Orduz R, Morales OL, Martínez Ó, Baldión M, Isaza MA. Leucemia/linfoma T del adulto en pacientes infectados con HTLV-1: reporte de dos casos de Colombia. Biomédica. 2013;33:519-25. http://dx.doi.org/10.7705/biomedica.v33i4.1429
Di Lorenzo-Oliveira C, Loureiro F, De Bastos MR, Proietti FA, Carneiro-Proietti AB. Blood donor deferral in Minas Gerais State, Brazil: Blood centers as sentinels of urban population health. Transfusion. 2009;49:851-7. http://dx.doi.org/10.1111/j.1537-2995.2008.02062.x
Whyte G. Is screening of Australian blood donors for HTLV-I necessary? Med J Aust. 1997;166:478-81.
Vrielink H, Reesink H. HTLV-I/II prevalence in different geographic locations. Transfus Med Rev. 2004;18:46-57. http://dx.doi.org/10.1016/j.tmrv.2003.10.004
Hewitt PE, Davison K, Howell DR, Taylor GP. Human T-lymphotropic virus lookback in NHS Blood and Transplant (England) reveals the efficacy of leukoreduction. Transfusion. 2013;53:2168-75. http://dx.doi.org/10.1111/trf.12105
Pomper G, Wu Y, Snyder E. Risks of transfusion-transmitted infections: 2003. Curr Opin Hematol. 2003;10:412-8.
Instituto Nacional de Salud. Circular No. 0082 de 2011. Pruebas confirmatorias de donantes de sangre serorreac-tivos. Fecha de consulta: 23 de mayo de 2015. Disponible en: http://www.ins.gov.co/lineas-de-accion/Red-Nacional-Laboratorios/Normatividad%20Red%20nal%20bancos%20de%20sangre/Circular%200082%20de%202011.pdf.
Ministerio de Salud y Protección Social. Resolución 437 de 2014. Fecha de consulta: 23 de mayo de 2015. Disponible en: https://www.minsalud.gov.co/Normatividad_Nuevo/Resoluci%C3%B3n%200437%20de%202014.pdf-
Manns A, Wilks RJ, Murphy EL, Haynes G, Figueroa JP, Barnett M, et al. A prospective study of transmission by transfusion of HTLV-I and risk factors associated with seroconversion. Int J Cancer. 1992;51:886-91.
Cortés A, Beltrán M, Gallego GA, Isaza LM. Estudio prospectivo seroepidemiológico de infección por el virus linfotrópico humano I y II (HTLV-I/II) en donantes de sangre de áreas colombianas endémicas y no endémicas. Colombia Médica.1999;30:19-25.
Carneiro-Proietti AB, Sabino EC, Leão S, Salles NA, Loureiro P, Sarr M, et al. Human T-lymphotropic virus type 1 and type 2 seroprevalence, incidence, and residual transfusion risk among blood donors in Brazil during 2007–2009. AIDS Res Hum Retroviruses. 2012;28:1265-72. http://doi.org/10.1089/aid.2011.0143
Chang YB, Kaidarova Z, Hindes D, Bravo M, Kiely N, Kamel H, et al. Seroprevalence and demographic determinants of human T-lymphotropic virus Type 1 and 2 infections among first-time blood donors-United States, 2000-2009. J Infect Dis. 2014;209:523-31. http://doi.org/10. 1093/infdis/jit497
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