Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia
Keywords:
Mycobacterium tuberculosis, tuberculosis, anti-infective agents, plants, medicinal, phytotherapy, Colombia
Abstract
Introduction. Human tuberculosis is a contagious-infectious disease mainly caused by Mycobacterium tuberculosis. Although regimens exist for treating tuberculosis, they are far from ideal. Development of effective strategies for treatment of human tuberculosis has posed a challenge, considering the increase in infections associated with the human immunodeficiency virus and immunocompromised patients. Essential oils -volatile, aromatic oil extracts from plants-have been used in traditional treatment of many diseases; however careful investigation of these oils has not been undertaken with respect to treatments of tuberculosis.Objective. The in vitro antitubercular activity of essential oils from 11 medicinal plants grown in Colombia were assessed for efficacy as new medications (phytomedicines) for treatment of M. tuberculosis H37Rv.
Material and methods. Essential oil extraction and analysis were performed as described Stashenko et al. (2004). Minimal inhibitory concentrations were determined by a colorimetric macrodilution method, following the protocol described by Abate et al. (1998). Isoniazide and rifampin were used as control treatments. Bactericidal and bacteriostatic activity was measured using the method developed by the Clinical and Laboratory Standards Institute consigned in the M26-A protocol.
Results. Essential oils from Achyrocline alata and Swinglea glutinosa were the most active with minimal inhibitory concentrations of 62.5±0.1 and 100±36 μg ml-1, respectively. Carvacrol, thymol, p-cymene, 1,8-cineole, limonene, and β-pinene were the major components ,most often identified in the 11 plant extracts of essential oils. Time-kill curve assays demonstrated the bacteriostatic activity of these essential oils.
Conclusions. The essential oils from A. alata and S. glutinosa plants, and the components identified therein, are candidates as potential phytotherapeutic agents for human tuberculosis control.
Downloads
Download data is not yet available.
References
1. Ducati RG, Ruffino-Netto A, Basso LA, Santos DS. The resumption of consumption-a review on tuberculosis. Mem Inst Oswaldo Cruz. 2006;101:697-714.
2. Zumla A, Grange J. Tuberculosis. BMJ. 1998; 316: 1962-4.
3. Chang Blanc D, Nunn P. Incentives and disincentives for new anti-tuberculosis drug development. Geneva: World Health Organization; 1999.
4. National Institute of Allergy and Infectious Diseases. NIAID Global Health Research Plan for HIV/AIDS, malaria, and tuberculosis. Bethesda: National Institute of Allergy and Infectious Diseases; 2001.
5. Heinrich M, Gibbons S. Ethnopharmacology in drug discovery: an analysis of its role and potential contribution. J Pharm Pharmacol. 2001;53:425-32.
6. Gautam R, Saklani A, Jachak SM. Indian medicinal plants as a source of antimycobacterial agents. J Ethnopharmacol. 2007;110:200-34.
7. Edris AE. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review. Phytother Res. 2007;21:308-23.
8. Cantrell CL, Franzblau SG, Fischer NH. Anti-myco-bacterial plant terpenoids. Planta Med. 2001;67:685-94.
1. Ducati RG, Ruffino-Netto A, Basso LA, Santos DS. The resumption of consumption-a review on tuberculosis. Mem Inst Oswaldo Cruz. 2006;101:697-714.
2. Zumla A, Grange J. Tuberculosis. BMJ. 1998; 316: 1962-4.
3. Chang Blanc D, Nunn P. Incentives and disincentives for new anti-tuberculosis drug development. Geneva: World Health Organization; 1999.
4. National Institute of Allergy and Infectious Diseases. NIAID Global Health Research Plan for HIV/AIDS, malaria, and tuberculosis. Bethesda: National Institute of Allergy and Infectious Diseases; 2001.
5. Heinrich M, Gibbons S. Ethnopharmacology in drug discovery: an analysis of its role and potential contribution. J Pharm Pharmacol. 2001;53:425-32.
6. Gautam R, Saklani A, Jachak SM. Indian medicinal plants as a source of antimycobacterial agents. J Ethnopharmacol. 2007;110:200-34.
7. Edris AE. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review. Phytother Res. 2007;21:308-23.
8. Cantrell CL, Franzblau SG, Fischer NH. Anti-myco-bacterial plant terpenoids. Planta Med. 2001;67:685-94.
2. Zumla A, Grange J. Tuberculosis. BMJ. 1998; 316: 1962-4.
3. Chang Blanc D, Nunn P. Incentives and disincentives for new anti-tuberculosis drug development. Geneva: World Health Organization; 1999.
4. National Institute of Allergy and Infectious Diseases. NIAID Global Health Research Plan for HIV/AIDS, malaria, and tuberculosis. Bethesda: National Institute of Allergy and Infectious Diseases; 2001.
5. Heinrich M, Gibbons S. Ethnopharmacology in drug discovery: an analysis of its role and potential contribution. J Pharm Pharmacol. 2001;53:425-32.
6. Gautam R, Saklani A, Jachak SM. Indian medicinal plants as a source of antimycobacterial agents. J Ethnopharmacol. 2007;110:200-34.
7. Edris AE. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review. Phytother Res. 2007;21:308-23.
8. Cantrell CL, Franzblau SG, Fischer NH. Anti-myco-bacterial plant terpenoids. Planta Med. 2001;67:685-94.
1. Ducati RG, Ruffino-Netto A, Basso LA, Santos DS. The resumption of consumption-a review on tuberculosis. Mem Inst Oswaldo Cruz. 2006;101:697-714.
2. Zumla A, Grange J. Tuberculosis. BMJ. 1998; 316: 1962-4.
3. Chang Blanc D, Nunn P. Incentives and disincentives for new anti-tuberculosis drug development. Geneva: World Health Organization; 1999.
4. National Institute of Allergy and Infectious Diseases. NIAID Global Health Research Plan for HIV/AIDS, malaria, and tuberculosis. Bethesda: National Institute of Allergy and Infectious Diseases; 2001.
5. Heinrich M, Gibbons S. Ethnopharmacology in drug discovery: an analysis of its role and potential contribution. J Pharm Pharmacol. 2001;53:425-32.
6. Gautam R, Saklani A, Jachak SM. Indian medicinal plants as a source of antimycobacterial agents. J Ethnopharmacol. 2007;110:200-34.
7. Edris AE. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review. Phytother Res. 2007;21:308-23.
8. Cantrell CL, Franzblau SG, Fischer NH. Anti-myco-bacterial plant terpenoids. Planta Med. 2001;67:685-94.
How to Cite
1.
Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W. Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia. biomedica [Internet]. 2009 Mar. 1 [cited 2024 May 19];29(1):51-60. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/41
Some similar items:
- John-Leonardo Torres-Castiblanco, Jorge Alberto Carrillo, Daniel Hincapié-Urrego, Adriana Rojas-Villarraga, Tuberculosis in the era of anti-TNF-alpha therapy: Why does the risk still exist? , Biomedica: Vol. 38 No. 1 (2018)
- Claudia Llerena, Angie Zabaleta, Angélica Valbuena, Martha Murcia, Prevalence of Mycobacterium tuberculosis resistance to quinolones and injectables in Colombia, 2012-2013 , Biomedica: Vol. 37 No. 1 (2017)
- Julio César Martínez, Claudia Llerena, Yanely Angélica Valbuena, The Importance of investigating Mycobacterium bovis in clinical samples of human origin , Biomedica: Vol. 39 No. Sp. 1 (2019): Suplemento 1, Microbiología médica, mayo
- Leandro Galvis, Ángel Y. Sánchez, Leonardo F. Jurado, Martha I. Murcia, Tuberculosis associated with tumor necrosis factor-α antagonists, case description and analysis of reported cases in Colombia , Biomedica: Vol. 38 No. 1 (2018)
- Diana Castaño, Mauricio Rojas, Alterations in recruitment and activation of Rab proteins during mycobacterial infection , Biomedica: Vol. 30 No. 2 (2010)
- Sonia Isabel Cuervo, Diego Andrés Bonilla, Martha Isabel Murcia, Johana Hernández, Julio César Gómez, Tuberculosis of the breast , Biomedica: Vol. 33 No. 1 (2013)
- Adriana Rojas-Villarraga, Carlos Andrés Agudelo, Ricardo Pineda-Tamayo, Alvaro Porras, Gustavo Matute, Juan Manuel Anaya, Tuberculosis in patientes treated with tumor necrosis factor alpha antagonists living in an endemic area. Is the risk worthwhile? , Biomedica: Vol. 27 No. 2 (2007)
- Luis F. García, Luis F. Barrera, Perspectives for new anti-tuberculous vaccines in the post-genomic era. , Biomedica: Vol. 24 (2004): Suplemento 1
- Alvaro Javier Idrovo, Historical, social and epidemiological roots of tuberculosis in Bogotá, Colombia. , Biomedica: Vol. 24 No. 4 (2004)
- Claudia Llerena, Santiago Elías Fadul, María Consuelo Garzón, Graciela Mejía, Dora Leticia Orjuela, Luz Mary García, Hilda Beatriz Álvarez, Fernando Javier Ruiz, Drug-resistant Mycobacterium tuberculosis in children under 15 years , Biomedica: Vol. 30 No. 3 (2010)
Issue
Section
Original articles
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |