Comparison of quick SOFA and SIRS scales at the bedside of patients with Staphylococcus aureus bacteremia
Abstract
Introduction: One of the primary causes of community-acquired bacteremia also associated with nosocomial infections is Staphylococcus aureus, which is responsible for a high percentage of complications leading to high morbidity and mortality rates. The systemic inflammatory response syndrome (SIRS) criteria have been traditionally used to evaluate the presence of sepsis; however, recent evidence questions its predictive value due to its low sensitivity and specificity. In 2016, new criteria for sepsis were published and a new tool emerged, quick SOFA (qSOFA), for the rapid evaluation of infection in emergency services.
Objective: To compare the qSOFA and SRIS tools for the prediction of bacteremia caused by S. aureus.
Materials and methods: We conducted an observational study in patients with S. aureus bacteremia to evaluate their phenotypic resistance patterns, some special features (sociodemographic characteristics, clinical and paraclinical values), complications, and mortality. The results of the qSOFA and SIRS scales were analyzed to identify which of them could better predict the presence of S. aureus bacteremia.
Results: Twenty-six bacteremic patients were identified. Staphylococcus aureus was the second most frequently isolated bacteria. The results evidenced a mortality rate of 50% (13 cases) and a prevalence of 30% of MRSA. For the clinical scores evaluated, the qSOFA scale was positive in 30.8% of the patients, and the SIRS scale, in 92.3%.
Discussion: The mortality rate for the population under study was high and the qSOFA tool had a lower diagnostic yield compared to the classic criteria for SIRS.
Downloads
References
Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101:1644-55. https://doi.org/10.1378/chest.101.6.1644
Kaukonen K, Bailey M, Pilcher D, Cooper J, Bellomo R. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med. 2015;372:1629-38. https://doi.org/10.1056/NEJMoa1415236
Álvaro-Meca A, Jiménez-Sousa MA, Micheloud D, Sánchez-López A, Heredia-Rodríguez M, Tamayo E, et al. Epidemiological trends of sepsis in the twenty-first century (2000-2013): An analysis of incidence, mortality, and associated costs in Spain. Popul Health Metr. 2018;16:4. https://doi.org/10.1186/s12963-018-0160-x
Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 200634:1589-96. https://doi.org/10.1097/01.CCM.0000217961.75225.E9
Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, et al. Assessment of clinical criteria for sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315:762-74. https://doi.org/10.1001/jama.2016.0288
Mylotte JM, Tayara A. Staphylococcus aureus bacteremia: Predictors of 30-day mortality in a large cohort. Clin Infect Dis. 2000;31:1170-4. https://doi.org/10.1086/317421
Keynan Y, Rubinstein E. Staphylococcus aureus bacteremia, risk factors, complications, and management. Crit Care Clin. 2013;29:547-62. https://doi.org/10.1016/j.ccc.2013.03.008
Tong SY, Davis JS, Eichenberger E, Holland TL, Fowler VG Jr. Staphylococcus aureus infections: Epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev. 2015;28:603-61. https://doi.org/10.1128/CMR.00134-14
Cecconi M, Evans L, Levy M, Rhodes A. Sepsis and septic shock. Lancet. 2018;392:75-87. https://doi.org/10.1016/S0140-6736(18)30696-2
Wang J, Hsu L, Lauderdale T, Fan W, Wang F. Comparison of outcomes among adult patients with nosocomial bacteremia caused by methicillin-susceptible and methicillin-resistant Staphylococcus aureus: A retrospective cohort study. PLoS One. 2015;10:e0144710. https://doi.org/10.1371/journal.pone.0144710
Kaasch A, Barlow G, Edgeworth J, Fowler V, Hellmich M, Hopkins S, et al. Staphylococcus aureus bloodstream infection: A pooled analysis of five prospective, observational studies. J Infect. 2014;68:242-51. https://doi.org/10.1016/j.jinf.2013.10.015
Yilmaz M, Elaldi N, Balkan İ, Arslan F, Batırel A, Bakıcı M, et al. Mortality predictors of Staphylococcus aureus bacteremia: A prospective multicenter study. Ann Clin Microbiol Antimicrob. 2016;15:7. https://doi.org/10.1186/s12941-016-0122-8
Serafim R, Gomes J, Salluh J, Póvoa P. A comparison of the quick-SOFA and systemic inflammatory response syndrome criteria for the diagnosis of sepsis and prediction of mortality: A systematic review and meta-analysis. Chest. 2018;153:646-55. https://doi.org/10.1016/j.chest.2017.12.015
Minejima E, Delayo V, Lou M, Pamela N, Nieberg P, Rosemary C, et al. Utility of qSOFA score in identifying patients at risk for poor outcome in Staphylococcus aureus bacteremia. BMC Infect Dis. 2019;19:149. https://doi.org/10.1186/s12879-019-3770-4
Yu H, Nie L, Liu A, Wu K, Hsein Y, Yen D, et al. Combining procalcitonin with the qSOFA and sepsis mortality prediction. Medicine (Baltimore). 2019;98:e15981. https://doi.org/10.1097/MD.0000000000015981
Chang S, Yeh C, Chen Y, Hsu C, Chen J, Chen W, et al. Quick-SOFA score to predict mortality among geriatric patients with influenza in the emergency department. Medicine (Baltimore). 2019;98:e15966. https://doi.org/10.1097/MD.0000000000015966
Herzke CA, Chen LF, Anderson DJ, Choi Y, Sexton DJ, Kaye KS. Empirical antimicrobial therapy for bloodstream infection due to methicillin-resistant Staphylococcus aureus: No better than a coin toss. Infect Control Hosp Epidemiol. 2009;30:1057-61. https://doi.org/10.1086/606163
Carvalho K, Mamizuka E, Gontijo F. Methicillin/oxacillin-resistant Staphylococcus aureus as a hospital and public health threat in Brazil. Braz J Infect Dis. 2010;14:71-6. https://doi.org/10.1016/S1413-8670(10)70014-3
Shurland S, Zhan M, Bradham DD, Roghmann MC. Comparison of mortality risk associated with bacteremia due to methicillin-resistant and methicillin-susceptible Staphylococcus aureus. Infect Control Hosp Epidemiol. 2007;28:273-9. https://doi.org/10.1086/512627
Some similar items:
- Liliana I. Barrero, Juan S. Castillo, Aura L. Leal, Ricardo Sánchez, Jorge A. Cortés, Carlos A. Álvarez, Andrés L. González, Economic burden of methicillin-resistant Staphylococcus aureus bacteremia in critical care patients in hospitals in Bogotá , Biomedica: Vol. 34 No. 3 (2014)
- Freddy Israel Pantoja, Willinton Robert Ricaurte , Diana Elizabeth Rosero , Relationship between death and admission of pediatric patients to intensive care due to Staphylococcus aureus bacteremia acquired in the community, 2014-2017 , Biomedica: Vol. 41 No. 1 (2021)
- Heidy C. Martínez-Díaz, Sandra L. Valderrama-Beltrán, Ana C. Hernández, Silvia K. Pinedo, Juan R. Correa, Édgar G. Ríos, Julie J. Rojas, Yessica Y. Hernández, Marylin Hidalgo, Methicillin-resistant Staphylococcus aureus nasal colonization in cardiovascular surgery patients at a university hospital in Bogotá, Colombia , Biomedica: Vol. 40 No. Supl. 1 (2020): Mayo, Infecciones en el trópico
- Natalie Nader, Ramón Iván Medina, Luz Ángela Pescador, Barbarita María Mantilla, Juan Sebastián Bravo, Carlos Hernando Gómez, Characterization of patients with bacteremia by methicillin-resistant Staphylococcus aureus in a high-complexity military hospital , Biomedica: Vol. 39 No. Sp. 1 (2019): Suplemento 1, Microbiología médica, mayo
- Martine Bonnaure-Mallet, Paula Juliana Pérez-Chaparro, Patrice Gracieux, Vincent Meuric, Zohreh Tamanai-Shacoori, Jaime Eduardo Castellanos, Distribution of Porphyromonas gingivalis fimA genotypes in isolates from subgingival plaque and blood sample during bacteremia , Biomedica: Vol. 29 No. 2 (2009)
- César A. Arias, Marylin Hidalgo, Jinnethe Reyes, Ana María Cárdenas, Lorena Díaz, Sandra Ríncon, Natasha Vanegas, Paula Lucía Díaz, Elizabeth Castañeda, Resistance profiles to fluoroquinolones in clinical isolates of Gram positive cocci , Biomedica: Vol. 28 No. 2 (2008)
- José Y. Rodríguez, Carolina Duarte , Gerson J. Rodríguez , Lucy Angeline Montaño, Miguel A. Benítez-Peñuela , Paula Díaz , Olga López, Carlos A. Álvarez-Moreno , Bacteremia by non-O1/non-O139 Vibrio cholerae: Case description and literature review , Biomedica: Vol. 43 No. 3 (2023)
- Ana María Perilla, Camilo González, Sandra Liliana Valderrama, Natasha Vanegas, Bibiana Chavarro, Luis Carlos Triana, José Roberto Támara, Carlos Arturo Álvarez, Necrotizing pneumonia by community-acquired, methicillin-resistant Staphylococcus aureus in Colombia , Biomedica: Vol. 29 No. 4 (2009)
- Narda María Olarte, Ismael Alberto Valderrama, Karlo Roberto Reyes, Martha Isabel Garzón, Javier Antonio Escobar, Betsy Esperanza Castro, Natasha Vanegas, Methicillin-resistant Staphylococcus aureus colonization in a Colombian hospital intensive care unit: phenotypic and molecular characterization , Biomedica: Vol. 30 No. 3 (2010)
- Javier Antonio Escobar, Ingrid Tatiana Gómez, Martha Johanna Murillo, Betsy Esperanza Castro, Bibiana Chavarro, Ricaurte Alejandro Márquez, Natasha Vanegas, Design of two molecular methodologies for the rapid identification of Colombian community-acquired methicillin-resistant Staphylococcus aureus isolates , Biomedica: Vol. 32 No. 2 (2012)
Article metrics | |
---|---|
Abstract views | |
Galley vies | |
PDF Views | |
HTML views | |
Other views |