Biochemical alterations as prediction markers for the severity of illness in dengue fever patients
Abstract
Introduction: Dengue is the most important mosquito-borne infection in the world. There is evidence supporting the use of biochemical alterations as prediction tools for severity of illness in dengue.
Objective: To evaluate biochemical alterations as potential prediction markers for severity in dengue.
Materials and methods: This was a case-control study nested in a cohort. We randomly selected 125 severe dengue cases and 120 controls with non-severe dengue for measuring LDH, CK, CRP andalbumin serum levels using acute phase sera. To evaluate the predictive value for each biomarker, we established cut-off points with 90% sensitivity in detecting severe cases.
Results: There was association among the CRP levels < 9.8 mg/L (OR=0.04; 95% CI=0.02-0.08;p=0.000), <400 U/L LDH levels (OR=0.49; 95% CI=0.24-1.02; p=0.053) and <4 mg/dl albumin levels (OR=3.46; 95% CI=1.96-6.12; p=0.000) with the severity of dengue. In contrast, the CK levels showed no association with the severity of the disease.
Conclusions: Our findings suggest an association of CRP, LDH and albumin levels with the severity of dengue. These biochemical tests could be used as predictive tools in the clinical course of the infection.
Downloads
Some similar items:
- Clara Beatriz Ocampo, Camila González, Carlos A. Morales, Mauricio Pérez, Dawn Wesson, Charles S. Apperson, Evaluation of community-based strategies for Aedes aegypti control inside houses , Biomedica: Vol. 29 No. 2 (2009)
- María Elena Cuéllar-Jiménez, Olga Lucía Velásquez-Escobar, Ranulfo González-Obando, Carlos Andrés Morales-Reichmann, Detection of Aedes albopictus (Skuse) (Diptera: Culicidae) in the city of Cali, Valle del Cauca, Colombia , Biomedica: Vol. 27 No. 2 (2007)
- Natalia Houghton-Triviño, Katherine Martín, Kris Giaya, Jairo A. Rodríguez, Irene Bosch, Jaime E. Castellanos, Comparison of the transcriptional profiles of patients with dengue fever and dengue hemorrhagic fever reveals differences in the immune response and clues in immunopathogenesis , Biomedica: Vol. 30 No. 4 (2010)
- Berta Nelly Restrepo, Margarita Arboleda, Ruth Ramírez, Gonzalo Álvarez, Serum platelet-activating factor acetylhydrolase activity in dengue patients of African or mestizo descendency , Biomedica: Vol. 31 No. 4 (2011)
- Sandy Milena Caldera, María Cristina Jaramillo, Suljey Cochero, Alveiro Pérez-Doria, Eduar Elías Bejarano, Genetic differences between populations of Aedes aegypti from municipalities in northern Colombia, with high and low dengue incidence , Biomedica: Vol. 33 (2013): Suplemento 1, Fiebres hemorrágicas
- Raquel E. Ocazionez-Jiménez, Ayda Susana Ortiz-Báez, Sergio Yebrail Gómez-Rangel, Daniel R. Miranda-Esquivel, Dengue virus serotype 1 (DENV-1) from Colombia: its contribution to dengue occurrence in Santander , Biomedica: Vol. 33 (2013): Suplemento 1, Fiebres hemorrágicas
- Mabel Carabalí, Clara Beatriz Ocampo, María Eugenia Toledo, Lyda Osorio, Mass communication of dengue surveillance data: effect of an intervention in Guadalajara de Buga, Colombia , Biomedica: Vol. 33 (2013): Suplemento 1, Fiebres hemorrágicas
- Luis Ángel Villar, Rosa Margarita Gélvez, Jairo Antonio Rodríguez, Doris Salgado, Beatriz Parra, Lyda Osorio, Irene Bosch, Biomarkers for the prognosis of severe dengue , Biomedica: Vol. 33 (2013): Suplemento 1, Fiebres hemorrágicas
- Susanne Ardila-Roldán, Liliana Santacoloma, Helena Brochero, Status of insecticide susceptibility of public health use in natural populations of Aedes aegypti (Diptera: Culicidae) of Casanare, Colombia , Biomedica: Vol. 33 No. 3 (2013)
- César A. Rodriguez, Diana C. Gallego, José A. González, Paola A. Luna, Mitzilene Navarro, Germán A. Ramírez, Mosquitoe breeding sites and fauna ln Armenia's urban area aiier the January 25, 1999, earthquake , Biomedica: Vol. 21 No. 2 (2001)
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
